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Intestinal Epithelial Axin1 Deficiency Protects Against Colitis via Altered Gut Microbiota

Shari Garrett,Yongguo Zhang,Yinglin Xia,Jun Sun,

Engineering doi: 10.1016/j.eng.2023.06.007

Abstract: essential for gastrointestinal development and homeostasis, and its dysregulation has been implicated in inflammationHere, we aim to demonstrate that intestinal Axin1 determines gut homeostasis and host response to inflammationThese data suggest non-colitogenic effects driven by the gut microbiome.Further mechanistic studies using specific Axin1 mutations elucidating how Axin1 modulates the microbiome

Keywords: Axin1     Bacteria     Microbiome inflammation     Inflammatory bowel disease     Immunity     Microbiome     Paneth cells     Akkermansia    

Integrated analysis of gut microbiome and host immune responses in COVID-19

Frontiers of Medicine 2022, Volume 16, Issue 2,   Pages 263-275 doi: 10.1007/s11684-022-0921-6

Abstract: Emerging evidence indicates that the gut microbiome contributes to the host immune response to infectiousHere, to explore the role of the gut microbiome in the host immune responses in COVID-19, we conductedWe found that the diversity of the gut microbiome was reduced in severe/critical COVID-19 cases comparedIn addition, an integrative analysis of gut microbiome and the transcriptome of peripheral blood mononuclear

Keywords: COVID-19     SARS-COV-2     gut microbiome     immune response    

Cytokines and inflammation in adipogenesis: an updated review

Ning Jiang, Yao Li, Ting Shu, Jing Wang

Frontiers of Medicine 2019, Volume 13, Issue 3,   Pages 314-329 doi: 10.1007/s11684-018-0625-0

Abstract: Meanwhile, chronic low-grade inflammation is commonly observed in obese populations.

Keywords: cytokines     inflammation     adipogenesis     type 2 diabetes mellitus     metabolic disorder    

Microbiome subsets determine tumor prognosis and molecular characteristics of clear-cell renal cell carcinoma: a multi-center integrated analysis of microbiome, metabolome, and transcriptome data

Frontiers of Medicine doi: 10.1007/s11684-023-1029-3

Abstract: Microbiome subsets determine tumor prognosis and molecular characteristics of clear-cell renal cell carcinoma: a multi-center integrated analysis of microbiome, metabolome, and transcriptome data

Keywords: tumor prognosis molecular     Microbiome subsets determine     center analysis microbiome     transcriptome data    

Appendiceal inflammation affects the length of stay following appendicectomy amongst children: a myth

Khurram Siddique, Shirin Mirza, Gandra Harinath

Frontiers of Medicine 2013, Volume 7, Issue 2,   Pages 264-269 doi: 10.1007/s11684-013-0259-1

Abstract:

The effect of the severity of appendiceal inflammation on post-operative stay in children followingThis study was conducted to determine the association between the severity of appendiceal inflammationThe association of the severity of appendiceal inflammation and post-operative stay was assessed by multivariableMacroscopically perforated appendix, histological inflammation and post-operative complications wereperforated appendix or post-operative complications while it remained unaffected by the histological inflammation

Keywords: appendiceal inflammation     post-operative stay     paediatrics    

Understanding building-occupant-microbiome interactions toward healthy built environments: A review

Shuai Li, Zhiyao Yang, Da Hu, Liu Cao, Qiang He

Frontiers of Environmental Science & Engineering 2021, Volume 15, Issue 4, doi: 10.1007/s11783-020-1357-3

Abstract: Abstract • The built environment, occupants, and microbiomes constitute an integrated ecosystem. • This review summarizes research progress which has focused primarily on microbiomes. • Critical research needs include studying impacts of occupant behaviors on microbiomes. Built environments, occupants, and microbiomes constitute a system of ecosystems with extensive interactions that impact one another. Understanding the interactions between these systems is essential to develop strategies for effective management of the built environment and its inhabitants to enhance public health and well-being. Numerous studies have been conducted to characterize the microbiomes of the built environment. This review summarizes current progress in understanding the interactions between attributes of built environments and occupant behaviors that shape the structure and dynamics of indoor microbial communities. In addition, this review also discusses the challenges and future research needs in the field of microbiomes of the built environment that necessitate research beyond the basic characterization of microbiomes in order to gain an understanding of the causal mechanisms between the built environment, occupants, and microbiomes, which will provide a knowledge base for the development of transformative intervention strategies toward healthy built environments. The pressing need to control the transmission of SARS-CoV-2 in indoor environments highlights the urgency and significance of understanding the complex interactions between the built environment, occupants, and microbiomes, which is the focus of this review.

Keywords: Microbiome     Built Environment     Occupant     Health    

for preventing peritoneal fibrosis in peritoneal dialysis patients: new insights based on peritoneal inflammation

Zhen Zhang, Na Jiang, Zhaohui Ni

Frontiers of Medicine 2017, Volume 11, Issue 3,   Pages 349-358 doi: 10.1007/s11684-017-0571-2

Abstract: Inflammation and angiogenesis are key events during the pathogenesis of peritoneal fibrosis.peritoneal fibrosis and recent research progress on key fibrogenic molecular mechanisms in peritoneal inflammationFurthermore, novel strategies targeting peritoneal inflammation and angiogenesis to preserve the PM are

Keywords: peritoneal dialysis     peritoneal fibrosis     inflammation     angiogenesis    

Meter-scale variation within a single transect demands attention to taxon accumulation curves in riverine microbiome

Frontiers of Environmental Science & Engineering 2022, Volume 16, Issue 5, doi: 10.1007/s11783-022-1543-6

Abstract:

● Riverine microbiomes exhibited hyperlocal variation within a single transect.

Keywords: Microbiome     Freshwater     Taxon accumulation curve     Community assembly    

Human microbiome and prostate cancer development: current insights into the prevention and treatment

Solmaz Ohadian Moghadam, Seyed Ali Momeni

Frontiers of Medicine 2021, Volume 15, Issue 1,   Pages 11-32 doi: 10.1007/s11684-019-0731-7

Abstract: The human microbiome may influence prostate cancer development.several studies have focused on the effect of prostate infections as well as the composition of the human microbiomeIn healthy individuals, the microbiome plays a crucial role in the maintenance of homeostasis of bodyhealth problems, including malignancy through affecting systemic immune responses and creating systemic inflammationFurthermore, we discuss strategies to target the microbiome for risk assessment, prevention, and treatment

Keywords: microbiome     prostate cancer     prevention     treatment     molecular pathological epidemiology (MPE)     biomarker    

Particulate matter 2.5 triggers airway inflammation and bronchial hyperresponsiveness in mice by activating

Frontiers of Medicine 2021, Volume 15, Issue 5,   Pages 750-766 doi: 10.1007/s11684-021-0839-4

Abstract: Exposure to particulate matter 2.5 (PM2.5) potentially triggers airway inflammation by activating nuclearSirtuin 2 (SIRT2) is a key modulator in inflammation.However, the function and specific mechanisms of SIRT2 in PM2.5-induced airway inflammation are largelyThe activation of p65 triggered airway inflammation, increment of mucus secretion by goblet cells, andMeanwhile, p65 phosphorylation and acetylation, airway inflammation, and bronchial hyperresponsiveness

Keywords: particulate matter 2.5     sirtuin 2     p65     airway inflammation     bronchial hyperresponsiveness     triptolide    

Meter-scale variation within a single transect demands attention to taxon accumulation curves in riverine microbiome

Frontiers of Environmental Science & Engineering 2022, Volume 16, Issue 6, doi: 10.1007/s11783-022-1560-5

Comparative analysis of impact of human occupancy on indoor microbiomes

Frontiers of Environmental Science & Engineering 2021, Volume 15, Issue 5, doi: 10.1007/s11783-020-1383-1

Abstract:

• Exposure to indoor microbiomes is a public health concern in educational facilities.

Keywords: Built environment     Indoor microbiome     Occupant     Building     Sequencing    

Endothelial dysfunction in COVID-19 calls for immediate attention: the emerging roles of the endothelium in inflammation

Weijian Hang, Chen Chen, Xin A. Zhang, Dao Wen Wang

Frontiers of Medicine 2021, Volume 15, Issue 4,   Pages 638-643 doi: 10.1007/s11684-021-0831-z

Abstract: of overwhelming inflammatory responses in the pathogenesis of COVID-19 and the effectiveness of anti-inflammation

Keywords: COVID-19     endothelial dysfunction     inflammation reaction     cytokine storm    

Antibiotics-mediated intestinal microbiome perturbation aggravates tacrolimus-induced glucose disorders

Yuqiu Han, Xiangyang Jiang, Qi Ling, Li Wu, Pin Wu, Ruiqi Tang, Xiaowei Xu, Meifang Yang, Lijiang Zhang, Weiwei Zhu, Baohong Wang, Lanjuan Li

Frontiers of Medicine 2019, Volume 13, Issue 4,   Pages 471-481 doi: 10.1007/s11684-019-0686-8

Abstract: The altered components of gut microbiome and predicted microbial functional profiles showed significantIn conclusion, ABX aggravated the effect of TAC on the microbiome and its metabolic capacities, whichThese findings suggest that the ABX-altered microbiome can amplify the diabetogenic effect of TAC and

Keywords: antibiotics     tacrolimus     glucose disorders     microbiome    

Emerging Trends for Microbiome Analysis: From Single-Cell Functional Imaging to Microbiome Big Data

Jian Xu, Bo Ma, Xiaoquan Su, Shi Huang, Xin Xu, Xuedong Zhou, Wei Huang, Rob Knight

Engineering 2017, Volume 3, Issue 1,   Pages 66-70 doi: 10.1016/J.ENG.2017.01.020

Abstract:

Method development has always been and will continue to be a core driving force of microbiome scienceIn this perspective, we argue that in the next decade, method development in microbiome analysis willdata analysis to microbiome data science.Some of the recent method-development efforts by Chinese microbiome scientists and their internationalIt is our belief that the China Microbiome Initiative has the opportunity to deliver outstanding &ldquo

Keywords: Microbiome     Methoddevelopment     Single-cell analysis     Big data     China Microbiome Initiative    

Title Author Date Type Operation

Intestinal Epithelial Axin1 Deficiency Protects Against Colitis via Altered Gut Microbiota

Shari Garrett,Yongguo Zhang,Yinglin Xia,Jun Sun,

Journal Article

Integrated analysis of gut microbiome and host immune responses in COVID-19

Journal Article

Cytokines and inflammation in adipogenesis: an updated review

Ning Jiang, Yao Li, Ting Shu, Jing Wang

Journal Article

Microbiome subsets determine tumor prognosis and molecular characteristics of clear-cell renal cell carcinoma: a multi-center integrated analysis of microbiome, metabolome, and transcriptome data

Journal Article

Appendiceal inflammation affects the length of stay following appendicectomy amongst children: a myth

Khurram Siddique, Shirin Mirza, Gandra Harinath

Journal Article

Understanding building-occupant-microbiome interactions toward healthy built environments: A review

Shuai Li, Zhiyao Yang, Da Hu, Liu Cao, Qiang He

Journal Article

for preventing peritoneal fibrosis in peritoneal dialysis patients: new insights based on peritoneal inflammation

Zhen Zhang, Na Jiang, Zhaohui Ni

Journal Article

Meter-scale variation within a single transect demands attention to taxon accumulation curves in riverine microbiome

Journal Article

Human microbiome and prostate cancer development: current insights into the prevention and treatment

Solmaz Ohadian Moghadam, Seyed Ali Momeni

Journal Article

Particulate matter 2.5 triggers airway inflammation and bronchial hyperresponsiveness in mice by activating

Journal Article

Meter-scale variation within a single transect demands attention to taxon accumulation curves in riverine microbiome

Journal Article

Comparative analysis of impact of human occupancy on indoor microbiomes

Journal Article

Endothelial dysfunction in COVID-19 calls for immediate attention: the emerging roles of the endothelium in inflammation

Weijian Hang, Chen Chen, Xin A. Zhang, Dao Wen Wang

Journal Article

Antibiotics-mediated intestinal microbiome perturbation aggravates tacrolimus-induced glucose disorders

Yuqiu Han, Xiangyang Jiang, Qi Ling, Li Wu, Pin Wu, Ruiqi Tang, Xiaowei Xu, Meifang Yang, Lijiang Zhang, Weiwei Zhu, Baohong Wang, Lanjuan Li

Journal Article

Emerging Trends for Microbiome Analysis: From Single-Cell Functional Imaging to Microbiome Big Data

Jian Xu, Bo Ma, Xiaoquan Su, Shi Huang, Xin Xu, Xuedong Zhou, Wei Huang, Rob Knight

Journal Article